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“Enabling Technologies for Personalized and Precision Medicine”

Making a difference for the patients – 4bases’ paper of the month

“Enabling Technologies for Personalized and Precision Medicine”[1]

Whereas last month we have read about practical examples of the application of NGS-based methods in diagnostics and Precision Medicine, specifically the targeting of DNA repair mechanisms in cancer treatment[2], this month’s paper highlights key technological breakthroughs and remaining challenges in Personalized and Precision Medicine. Reviewing a number of enabling technologies from bioengineering to artificial intelligence it shows how much and how fast medicine is moving away from its old “one size fits all“ mentality toward personalized and precision medicine.  Molecular characterization of individual tumors is one of the outsets of personalized medicine and is essential in exploiting current and developing novel therapeutic opportunities, in a process called genome-guided therapy. Indeed, the latter includes the three components: pharmacogenomics, electronic medical records and genome sequencing/actionable gene identification.

There is no doubt that, as we’re moving toward a more precise future for oncology, the medical community will need precise answers to new molecular diagnostic questions. While only a minority of oncology patients currently benefit from genomic matching to targeted therapies, this population needs to continue its expansion driven by the advances in technology and knowledge.

4bases, which role is to develop and produce CE IVD and RUO reagent kits, proudly contributes to the ongoing medical revolution also by sharing and commenting information extracted from the abundant scientific literature on the topic.

4bases: when precision makes a difference.

[1] Ho D, Quake SR, McCabe ERB, et al. Enabling Technologies for Personalized and Precision Medicine. Trends Biotechnol. 2020;38(5):497‐ Go to DOI: 10.1016/j.tibtech.2019.12.021

[2] https://4bases.ch/targeting-dna-repair-in-cancer-current-state-and-novel-approaches-4bases-paper-of-the-month/

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