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Since March 2023, Oxford Nanopore Technologies plc (Oxford Nanopore) and 4bases (a Switzerland-based company specializing in kits for sequencing and bioinformatic tools), have been in collaboration to allow 4bases kits to be available on Oxford Nanopore sequencing technology (see press release here). Currently the following 4bases’ kits are compatible with Oxford Nanopore sequencing devices (see list below). This collaboration allows 4bases to propose an end-to-end solution to the market, from Library preparation, Sequencing devices, to Data Analysis.
4bases BRaCA panel is a kit for the identification of mutations in BRCA1 and BRCA2 genes through a molecular protocol for Next Generation Sequencing (NGS) technologies on Oxford Nanopore platforms. The kit is validated for germline and somatic analysis (SNVs, CNVs) of DNA extracted from blood samples and tissues (fresh, frozen or FFPE).
4bases CFTR panel kit is a kit for the identification of mutations in CFTR gene through a molecular protocol for Next Generation Sequencing (NGS) technologies on Oxford Nanopore platforms. The kit is validated for germline analysis (SNVs, CNVs) of DNA extracted from blood samples and tissues (fresh, frozen or FFPE).
4bases ClinEX pro kit is designed to detect genetic factors responsible of disease conditions not attributable to known pathologies, genetically heterogeneous diseases, and complex syndromic pictures. The kit targets more than 10,000 genes described in OMIM as related to known pathologies, plus ~130 hotspots, SNVs, deep intronic regions with a correlation to known hereditary diseases. Mitochondrial genes (as described in MitoMap) are also optionally covered and can be included in the analysis as needed. The total target size of ClinEX pro is 19.5 Mb and is optimized for Oxford Nanopore‘s Next Generation Sequencing (NGS) platforms. The complete table of target genes can be accessible upon request.
4bases HEVA pro is a kit for the identification of mutations in genes involved in Breast and Ovary cancer, familial adenomatous polyposis (FAP), and hereditary nonpolyposis colorectal cancer (HNPCC). HEVA pro allows to detect variants linked to a defect in homologous recombination deficiency (HRD) mechanism. Consequences of HRD defects causes error-prone DNA repair pathways, resulting in increased genomic instability which may be responsible for susceptibility to poly- (ADP) -ribose polymerase (PARPis) inhibitors. HEVA pro is a kit for the analysis of 50 genes using Oxford Nanopore‘s Next Generation Sequencing (NGS) platforms. The kit is validated for germline and somatic analysis (SNVs, CNVs) of DNA.
New kits are currently under validation process, please contact us for any further information you may need.
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