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Breast cancer is the leading cause of cancer-related deaths amongst women worldwide. One of the critical challenges in treating this disease is the presence of

In the 1990s, it was discovered that inherited loss-of-function pathogenic variants in the BRCA1 and BRCA2 genes (referred to as BRCA1/2 PVs) were linked to an increased familial risk of early-onset

Mendelian diseases, such as cystic fibrosis and thalassemia, are defined to be caused by mutations present in a single gene, which yield a series of